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The term peripheral arterial obstructive (or obliterating) disease (PAOD) of the lower limbs refers to the set of morbid conditions characterised by obstructive or steno-obstructive lesions located in the arterial districts downstream of the renal arteries, which imply a reduction of the perfusion in the lower limbs, regardless of their nature.

Peripheral arteriopathy is one of the most frequent manifestations of atherosclerotic disease. PAOD is present in 4-12% of subjects in the 55-70 age group, and its prevalence increases with age (1).

Smoking, obesity, dyslipidaemia and diabetes are major risk factors for PAOD

Intermittent claudication, in patients with peripheral arterial disease, is a cramp-type pain generally located at the level of a lower limb and occurs mainly following physical exercise, even bland.
2 Patients out of 100, with symptoms of intermittent claudication, undergo amputation within 5 years of diagnosis.

IC is considered a symptom of Arteriosclerosis
Cardiovascular mortality, particularly by myocardial infarction and stroke, is 3-4 times greater than for subjects of the same age and gender without IC


Current therapies

The first therapeutic approach to PAOD is to avoid the causes of the disease.

Should this not be enough and should there be no reduction in symptoms even by increasing the physical activity, it is necessary to consider therapies of a pharmacological (Cilostazol, Naftidrofuryl, Oxpentifylin, Inositol nicotinate, Cinnarizine, Anticoagulants, Statins) or Interventional (Angioplasty, Stenting) and finally, Surgical (Bypass) type

The therapy developed by Quantix Swiss

1Peach G, Griffit M, Jones KG Diagnosis and management of peripheral arterial disease. Br Med J 2012;345:e5208